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The morphological and functional changes of the lungs in the early phase of blast injurywere analyzed and related quantitatively in rats with microcomputer-assisted morphometry.It wasfound that（1）significant or partial correlation exists between stereological and functional indices

（2）changes of the endothelium and epithelium rather than the interstitium contribute to the increase ofharmonic and arithmetic thickness(T

ht

T

at

)of the air-blood barrier

and（3）the regression equa-tions are as follows:（a）PaO

2

=3.56+1.62DL（O

2

）

r=0.678

P=0.032:（b）PaO

2

=2.99+3.49DL（O

2

）-0.0005S

A

+0.003S

c

-38.2V

c

-0.257T

ap

-0.028Dt（O

2

）

r

y

=0.9999

P=0.008;（c）PaCO

2

=7.69+0.0001S

A

-4.35T

at

+19.7T

ht

-46.2T

hp

-4.4T

aen

-5.87T

aep

r

y

=0.9999

P=0.014;（d）pH=3.068+0.0005S

A

-1.79T

at

+12.2T

ht

-50.8T

hp

-2.52T

aint

+0.69DL（O

2

）

r

y

=0.9999

P=0.10.The significance and application of stereology in theestablishment of the quantitative relationship between morphological and functional indices are dis-cussed.Mathematical models to relate morphometric parameters to functional changes are possible.