<正> The mitechondrial respiratory rate（S）of hepatocytes

respiratory control ratio（RCR）

oxidative phosphorylation effidency（ADP/O）

and hepatic ATP level were determined in ratswith acute obstructive cholangitis（AOC）to observe the changes of mitochondrial respiration

andthe therapeutic effects of verapamil and dexamethasone on the changes were assessedIt was found that S especially its state IV was significantly accelerated and RCR

ADP/O

and ATP level of the liver decreased at 6h after AOC

but in those rats treated with verapamilor dexamethasone

no significant changes of these parameters were observed in 48 h period afterAOC.These facts suggest that in the early stage of AOC

severe impairment of the mitochondrialrespiratory function and disturbance of energy metabolism could be present

but verapamil anddexamethasone could effectively prevent these damages from occurring.