Influence of four kinds of polysaccharides on the induction of lymphokine-activated killer cells in vitro
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Influence of four kinds of polysaccharides on the induction of lymphokine-activated killer cells in vitro
Military Medical ResearchIssue 1, Pages: 5-11(1993)
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Department of Microbiology Second Military Medical University Shanghai,200433
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Published:1993
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[1]曹广文,杜平,焦炳华,郑杭民.Influence of four kinds of polysaccharides on the induction of lymphokine-activated killer cells in vitro[J].Journal of Medical Colleges of PLA,1993(01):5-11.
DOI:
[1]曹广文,杜平,焦炳华,郑杭民.Influence of four kinds of polysaccharides on the induction of lymphokine-activated killer cells in vitro[J].Journal of Medical Colleges of PLA,1993(01):5-11.DOI:
Influence of four kinds of polysaccharides on the induction of lymphokine-activated killer cells in vitro
摘要
Abstract
<
正
>
Effects of Lycium barbarum polysaccharide(LBP)
Astragalus polysaccharide(APS)
polysaccharide of Acanthopanax senticosus(PAS)and polysaccharide of bacteriallipopolysaccharide(PS)on the induction of lymphokine-activated killer(LAK)cells fromC57BL/6 murine splenocytes were studied using [
125
I]UdR release assay.The fourpolysaccharides alone were shown to induce no cytotoxicity.When combined with humanrecombination interleukin-2(rlL-2)
they augmented LAK cell activities in adose-dependent manner
most markedly at 0.01~0.1 mg·ml
-1
for LBP
0.01 mg·ml
-1
forAPS and PAS
and 0.01 μg·ml
-1
for PS.They increased LAK cell activity in a shortrange of rIL-2 concentrations(250~1000U·ml
-1
).They were shown to inhibit LAK cellactivity when used beyond the suitable dosage.
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