The effects of tumor necrosis factor on cultured hepatocytes and non-parenchymal liver ceils in the mouse

王宇明; 大西弘生; 武藤泰敏; 刘沛

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The effects of tumor necrosis factor on cultured hepatocytes and non-parenchymal liver ceils in the mouse

Updated：2026-03-12

- The effects of tumor necrosis factor on cultured hepatocytes and non-parenchymal liver ceils in the mouse
- Military Medical Research Issue 3, Pages: 287-290(1992)
- Affiliations：
  
  1. Department of Infectious Diseases Southwest Hospital
  2. Third Military Medical College
  3. Gaotanyan Chongqing
  4. ,11003
  5. First Department of Internal Medicine
  6. Gifu University School of Medicine
  7. Third affiliated Hospital
  8. China Medical University
- Author bio：
- Funds：
- DOI：
  CLC：
- Published：1992
- Accepted：
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[1]王宇明,大西弘生,武藤泰敏,刘沛.The effects of tumor necrosis factor on cultured hepatocytes and non-parenchymal liver ceils in the mouse[J].Journal of Medical Colleges of PLA,1992(03):287-290.
DOI：

[1]王宇明,大西弘生,武藤泰敏,刘沛.The effects of tumor necrosis factor on cultured hepatocytes and non-parenchymal liver ceils in the mouse[J].Journal of Medical Colleges of PLA,1992(03):287-290. DOI：

摘要

Abstract

<正> The effects of tumor necrosis factor（TNF）on the cultured mouse hepa-tocytes and non-parenchymal liver cells were observed.It was found that therewere no significant changes of the morphological integrity and viability of thehepatocytes and the aspartate transferase level in the culture supernate after theaddition of TNF into the culture medium as compared with those of the normalcontrol

which indicates that TNF exerts no obvious cytotoxocity on the culturedmouse hepatocytes. In addition

there were also no significant changes of theabove mentioned parameters after TNF was added to the cocultures of hepato-cytes and non-parenchymal liver cells

which implies that the unactivated non-parenchymal liver cells are not involved in the TNF-related hepatocyte injury.

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