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Anti-hepatoma monoclonal antibodies HAb8

HAb18 IgG and HAb18 F（ab’）

2

were labelled with[

131

I]according to chloramine T method.The labelling rate andradioactivity were 51% and 9.58×10

4

Bq/mg

respectively.After administration of the[

131

I]-labelled conjugates through mouse tail vein

hepatoma xenografts were clearly im-aged

Localization index was 2.15

3.09

and 6.99 for HAb8

HAb18 IgG and HAb18F（ab’）

2

respectively.A total of 16 hepatoma-bearing nude mice（SMMU-LTNM）were di-vided into 4 groups.When xenografts reached 0.3cm in diameter

the treatment was be-gun by injection of the[

131

I]-conjugates through mouse tail vein.After 2 weeks of treat-ment

obvious inhibitory or killing effects on the xenografts were found.The tu-mor-bearing mice were killed during the period from 14 to 21d after treatment.Xenografts as well as other organs were sampled and viewed under light microscope ac-cording to routine procedure.The vital organs

such as heart

liver

spleen

lung

kidneyand brain showed no pathological lesions.In hepatoma xenografts

some tumor cellmembranes were found

with obscure cytoplasmic structure and increased eosinophilia

representing necrotic alterations.