Recognition with monoclonal antibodies of a Mr 71000 surface antigen of Plasmodium falciparum merozoites

蒋春雷; 徐荻; 管惟滨; 王笑利; 孔宪涛; 颜永碧

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Recognition with monoclonal antibodies of a Mr 71000 surface antigen of Plasmodium falciparum merozoites

Updated：2026-03-12

- Recognition with monoclonal antibodies of a Mr 71000 surface antigen of Plasmodium falciparum merozoites
- Military Medical Research Issue 1, Pages: 65-70(1993)
- Affiliations：
  
  1. Department of Parasitology Second Military Medical University Shanghai,200433
  2. Center of Clinical Immunology
  3. Changzheng Hospital
  4. Second Military Medical University Shanghai,200003
  5. Central Laboratory
- Author bio：
- Funds：
- DOI：
  CLC：
- Published：1993
- Accepted：
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[1]蒋春雷,徐荻,管惟滨,王笑利,孔宪涛,颜永碧.Recognition with monoclonal antibodies of a Mr 71000 surface antigen of Plasmodium falciparum merozoites[J].Journal of Medical Colleges of PLA,1993(01):65-70+74.
DOI：

[1]蒋春雷,徐荻,管惟滨,王笑利,孔宪涛,颜永碧.Recognition with monoclonal antibodies of a Mr 71000 surface antigen of Plasmodium falciparum merozoites[J].Journal of Medical Colleges of PLA,1993(01):65-70+74. DOI：

摘要

Abstract

<正> Merozoite surface antigens can induce protective immune responses and may becandidate antigens for malaria vaccine.Four hybridoma cell lines secreting monoclonalantibodies against Plasmodium falciparum Fcc7801/HN were produced.Antibodies fromthree of the four lines showed significant growth-inhibiting effect on P.falciparum invitro.One monoclonal antibody

known as C6

conjugated the antigen located exclusivelyon the merozoite surface and distributed evenly over the entire surface

as wasdemonstrated by immunoelectron microscopy.C6 also precipitated a single protein of Mr71000.

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