Effects of 5-HT and norepinephrine on the neuronal activities of the nucleus tractus solitarii in medullary slices

杨军; 包军; 徐茂锦; 苏定冯

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Effects of 5-HT and norepinephrine on the neuronal activities of the nucleus tractus solitarii in medullary slices

Updated：2026-03-12

- Effects of 5-HT and norepinephrine on the neuronal activities of the nucleus tractus solitarii in medullary slices
- Military Medical Research Issue 2, Pages: 184-187(1993)
- Affiliations：
  
  1. Department of Pharmacology Second Military Medical University
  2. ,200433
- Author bio：
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- Published：1993
- Accepted：
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[1]杨军,包军,徐茂锦,苏定冯.Effects of 5-HT and norepinephrine on the neuronal activities of the nucleus tractus solitarii in medullary slices[J].Journal of Medical Colleges of PLA,1993(02):184-187.
DOI：

[1]杨军,包军,徐茂锦,苏定冯.Effects of 5-HT and norepinephrine on the neuronal activities of the nucleus tractus solitarii in medullary slices[J].Journal of Medical Colleges of PLA,1993(02):184-187. DOI：

摘要

Abstract

<正> The relationship between 5-HT receptor and α-adrenoceptor was investigated inrat medullary slice preparations.In 57 nucleus tractus solitarii（NTS）neurons

47（82.5%）responded to both serotonin（5-HT）and norepinephrine（NE）.After synapse transmissionwas blocked by perfusion of artificial cerebrospinal fluid（ACSF）with low calcium andhigh magnesium

5 in 8 neurons were still sensitive to both 5-HT and NE.On the otherhand

3 in 5 neurons responding only to 5-HT or NA were sensitive to both 5-HT andNE after the synapse transmission blockage.In some neurons which exhibited excitatoryor inhibitory responses to 5-HT or NE alone

the responses were inversed when perfusedwith 5-HT and NE in combination.These results suggest that there may exist aninhibitory interaction between 5-HT receptors and α-adrenoceptors in NTS and that most5-HT and α-adrenoceptors coexist in the same NTS neurons.

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