Effects of amniotic fluid embolism-like plasma （AFEP） on the isolated perfused rabbit lungs （IPRL）were studied. It was found that AFEP could induce elevation of pulmonary artery pressure （PAP） and development of lung edema

which could be partially prevented by ibuprofen

a cycloxygenase inhibit0r

but amniotic fluid itself could not cause elevation of PAP and lung edema. The result suggests that AFEP-induced mediator from whole blood cells may be the important factor resulting in above-mentioned pathological changes.