<正> Objective: To study the effect of tacrolimus （Prograf

FK506） in preventing renal allograft rejection. Methods: The curative effect

therapy index

toxicity and side effects of FK506 were observed in 294 renal transplant recipients among whom 268 received FK506 24 h after the operation and the other 26 with cyclosporine （CsA） developed acute rejection after transplantation and were given FK506 to replace methyl-prednisolone （MP） when the latter did not result. All the patients were given oral mycophenolate mofetil （MMF

1. 0 g/d） and meticorten （Pred

30 mg/d） 24 h later after operation. Results: In the 268 recipients previously mentioned

the incidence of acute rejection was 10. 45%

glycometabolism disorder 9. 33%

nervous system disturbance 1. 59%

liver function abnormality 2. 99%

nephrotoxicity 1. 87%

gastrointestinal disorder 17. 5%

cytomegalovirus （CMV） viremia 2. 99%

and non-CMV pulmonary infection 1. 59% （4/268）

with 1 fatal case for cerebral hemorrhage with normal allograft function and a