An open add-on study on cyclophosphamide in patients with refractory myasthenic crisis

蒋建明; 涂来慧; 吴涛; 张仁琴; 丁素菊; 蔡建英

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An open add-on study on cyclophosphamide in patients with refractory myasthenic crisis

Updated：2026-03-12

- An open add-on study on cyclophosphamide in patients with refractory myasthenic crisis
- Military Medical Research Issue 1, Pages: 45-47(2003)
- Affiliations：
  
  1. Department of Neurology
  2. Changhai Hospital
  3. Second Military Medical University
  4. ,China
- Author bio：
- Funds：
- DOI：
  CLC： R741
- Published：2003
- Accepted：
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[1]蒋建明,涂来慧,吴涛,张仁琴,丁素菊,蔡建英.An open add-on study on cyclophosphamide in patients with refractory myasthenic crisis[J].Journal of Medical Colleges of PLA,2003(01):45-47.
DOI：

[1]蒋建明,涂来慧,吴涛,张仁琴,丁素菊,蔡建英.An open add-on study on cyclophosphamide in patients with refractory myasthenic crisis[J].Journal of Medical Colleges of PLA,2003(01):45-47. DOI：

摘要

Abstract

<正> Objective: To assess the efficacy and side effects of cyclophosphamide on refractory myasthenic crisis. Methods: Five patients of myasthenic crisis refractory to usual comprehensive treatment

entered an open additional study with cyclophosphamide 200 mg VD q. d or 400 mg VD q. o. d with 6-10 g of total dosage. The patients were followed up for 1-8 years. Results: All the 5 patients were effectively treated with obvious remission in 3 and improvement in 2. Two patients have returned to partial work. The side effects were tolerable. Conclusion: The present clinical trial showed that cyclophosphamide was effective

particularly in a long term as an additional therapy for treating MG patients with refractory crisis of myasthenia gravis.

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