Estrogen inhibits corticotropin-releasing hormone production in primary human placental cells

唐晓露; 倪鑫; 由振东; 何平; 惠宁; 顾清; 孙刚

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Estrogen inhibits corticotropin-releasing hormone production in primary human placental cells

Updated：2026-03-12

- Estrogen inhibits corticotropin-releasing hormone production in primary human placental cells
- Military Medical Research Issue 3, Pages: 183-185(2003)
- Affiliations：
  
  1. Department of Physiology
  2. College of Basic Medical Sciences
  3. Second Military Medical University
  4. ,China
  5. Department of Neurobiology
  6. Department of Obstetrics and Gynecology
  7. Changhai Hospital
- Author bio：
- Funds：
- DOI：
  CLC： R33
- Published：2003
- Accepted：
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[1]唐晓露,倪鑫,由振东,何平,惠宁,顾清,孙刚.Estrogen inhibits corticotropin-releasing hormone production in primary human placental cells[J].Journal of Medical Colleges of PLA,2003(03):183-185.
DOI：

[1]唐晓露,倪鑫,由振东,何平,惠宁,顾清,孙刚.Estrogen inhibits corticotropin-releasing hormone production in primary human placental cells[J].Journal of Medical Colleges of PLA,2003(03):183-185. DOI：

摘要

Abstract

<正> Objective: To study the inhibition effects of estrogen on the production of corticotropin-releasing hormonein human placental cells. Methods: Primary cultured placental cells were treated by ICI182

780

a complete ER an-tagonist

and Tamoxifen

an ERα-mixed agonist/antagonist and ERβ antagonist for 24 h. The supernatant was havestedfor the radioimmunoassay of CRH. Results: 17β-estradiol inhibited the secretion of corticotropin-releasing hormone inhuman placental （P<0.05）.ICI182

780 stimulated the secretion of corticotropin-releasing hormone in human pla-cental（P<0.05）. Conclusion: Estrogen represses the synthesis and secretion of corticotropin-releasing hormone inhuman placental

which is possibly mediated by ERα.

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