Effect of quercetin on expression of matrix metallo - proteinases and tissue inhibi tor of matalloproteinase -1 in cultured rat hepatic stellate cells

康鲁平; 齐荔红; 张俊平; 周斌

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Effect of quercetin on expression of matrix metallo - proteinases and tissue inhibi tor of matalloproteinase -1 in cultured rat hepatic stellate cells

Updated：2026-03-12

- Effect of quercetin on expression of matrix metallo - proteinases and tissue inhibi tor of matalloproteinase -1 in cultured rat hepatic stellate cells
- Military Medical Research Issue 1, Pages: 32-35(2003)
- Affiliations：
  
  1. Department of Pharmacy
  2. Fuzhou General Hospital
  3. PLA Nanjing Military Area Command
  4. Department of Pharmacology
  5. College of Pharmacy
  6. Military Medical University
  7. Military Medical University Fuzhou,350001
  8. ,Shanghai,200433
- Author bio：
- Funds：
- DOI：
  CLC： R575
- Published：2003
- Accepted：
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[1]康鲁平,齐荔红,张俊平,周斌.Effect of quercetin on expression of matrix metallo - proteinases and tissue inhibi tor of matalloproteinase -1 in cultured rat hepatic stellate cells[J].Journal of Medical Colleges of PLA,2003(01):32-35.
DOI：

[1]康鲁平,齐荔红,张俊平,周斌.Effect of quercetin on expression of matrix metallo - proteinases and tissue inhibi tor of matalloproteinase -1 in cultured rat hepatic stellate cells[J].Journal of Medical Colleges of PLA,2003(01):32-35. DOI：

摘要

Abstract

<正> Objective: To study the effects of quercetin （QU） on matrix metallo-proteinases （MMPs）

the tissue inhibitor of matalloproteinase-1 （TIMP-1）

procollagen I and 2 proteoglycans （decorin and biglycan） mRNA expression in cultured rat hepatic stellate cell line HSC-T6 cells. Methods: Cells were treated with different concentrations of QU （12. 5

50 μmol/L） or drug solvent （0. 1 % Me2SO） for 24 h. mRNA expression was determined by reverse transcription polymerase chain reaction （RT-PCR）. Results: QU （12.5 - 50 μmol/L） enhanced collagenase （rat MMP-13） and membrane typel-MMP （MMP-14） mRNA expression

decreased procollagen I mRNA expression in a concentration-dependent manner

but did not affect gelatinase-A （MMP-2）

TIMP-1

decorin and biglycan expression. Conclusion: QU may decrease matrix deposition and increase matrix degradation

which might be beneficial to liver fibrosis.

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