Immuohistochemical study on smooth muscle cell proliferation, pheno-typic modulation, and extracellular matrix accumulation in venous arterial grafts in rabbits

张卫达; 朱海龙

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Immuohistochemical study on smooth muscle cell proliferation, pheno-typic modulation, and extracellular matrix accumulation in venous arterial grafts in rabbits

Updated：2026-03-12

- Immuohistochemical study on smooth muscle cell proliferation, pheno-typic modulation, and extracellular matrix accumulation in venous arterial grafts in rabbits
- Military Medical Research Issue 2, Pages: 120-124(2002)
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  CLC： R654.4
- Published：2002
- Accepted：
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[1]张卫达,,,,,,,,,,朱海龙.Immuohistochemical study on smooth muscle cell proliferation, pheno-typic modulation, and extracellular matrix accumulation in venous arterial grafts in rabbits[J].Journal of Medical Colleges of PLA,2002(02):120-124.
DOI：

[1]张卫达,,,,,,,,,,朱海龙.Immuohistochemical study on smooth muscle cell proliferation, pheno-typic modulation, and extracellular matrix accumulation in venous arterial grafts in rabbits[J].Journal of Medical Colleges of PLA,2002(02):120-124. DOI：

摘要

Abstract

<正>Objective: To study the kinetics and distribution of smooth muscle cell （SMC） proliferation

phe-notypic modulation

and various extracellular matrix （ECM） components accumulation during vein graft remodeling. Methods: Normal vein and vein graft in carotid arteries were examined on d 4

d 7

d 14

d 60 and d180 after bypass grafting with immunohistochemical markers of cellular proliferation （proliferating cell nuclear antigen

PCNA）

cytoskeletal protein production （a-actin SMC）

myosin heavy chain (MHO iso-forms

ECM proteins

and histochemistry （hematoxylin eosin and Elastica-van Gieson stain）. Results: Normal veins demonstrated an extremely low level of cellular proliferation and expressed as adult phenotype SM-Cs in media. After bypass grafting

medial SMCs in the graft appeared to be damaged and began to proliferate on d 4

and subsequently migrated and formed the neointima on d 7. Thereafter

the neointima thickened throughout the 180-day period of the experiment

although the neointimal SMC prolif

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