<正> Objective: To prepare six quinazoline schiff bases by six steps of chemistry organic synthesis and test their inhibitory effect on hepatomacellular carcinoma cells HHCC and mammary cancer cell Bcap-37

furthmore

to compare their antitumor activities on these two kinds of cells. Methods: 2-Amino-5-nitro-benzylcarbonitrile was the initial material

and it was under the reaction of hydrolysis

ring-closing

halogenation

addition

reduction and substitution in turn to get the six quinazoline schiff bases

MTT method was adopted to compare their anticancer activities against the two cancer cells. Result and Conclusion: Six 6-imine-4-halo substituted anilinoquinozolines were prepared. The anti-cancer activities against both HHCC and Bcap-37were found

furthermore

they have more potency that on HHCC than on Bcap-37. In the six compounds

the schiff base Ⅵ is the most potent compound.