Effects of cholesterol liposomes on cytoskeleton and proliferation of rabbit sphincter of Oddi cells in culture

张劲松; 魏经国; 吴军正; 张淼丽; 王丹; 纪宗玲

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Effects of cholesterol liposomes on cytoskeleton and proliferation of rabbit sphincter of Oddi cells in culture

Updated：2026-03-12

- Effects of cholesterol liposomes on cytoskeleton and proliferation of rabbit sphincter of Oddi cells in culture
- Military Medical Research Issue 3, Pages: 167-170(2002)
- Affiliations：
  
  1. Department of Radiology
  2. Xijing Hospital
  3. Tangdu Hospital
  4. Department of Stomatology Biology
  5. Qindu Stomatology Hospital
  6. Department of anatomy
  7. Department of Biochemistry
  8. Fourth Military Medical University
  9. ,China
- Author bio：
- Funds：
- DOI：
  CLC： R33
- Published：2002
- Accepted：
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[1]张劲松,魏经国,吴军正,张淼丽,王丹,纪宗玲.Effects of cholesterol liposomes on cytoskeleton and proliferation of rabbit sphincter of Oddi cells in culture[J].Journal of Medical Colleges of PLA,2002(03):167-170+209.
DOI：

[1]张劲松,魏经国,吴军正,张淼丽,王丹,纪宗玲.Effects of cholesterol liposomes on cytoskeleton and proliferation of rabbit sphincter of Oddi cells in culture[J].Journal of Medical Colleges of PLA,2002(03):167-170+209. DOI：

摘要

Abstract

<正> Objective: To discuss the relationship between hypercholesterolemic disease and the functional and structural changes of Sphincter of Oddi （SO） by the study of effect of Cholesterol Liposome （CL） on structural and quantitative changes of SO cells. Methods: Rabbit SO was isolated for primary cell culture and subculture. After subcultured with different concentration of CL culture medium for 20 h

the structural and quantitative changes of SO cells were analyzed and detected by MTT-test

flow cytometer （FCM）

electronic microscope and electrophoresis technique respectively. Results: CL contributed a prominent stimulus to SO cells proliferation at middle concentration （<0. 5 - 0. 8 mg/ml）

which could be confirmed by FCM analysis which indicated the number of SO cells in S-phase increasing remarkably; however

high concentration of CL inhibited SO cells’ proliferation （>1. 0 mg/ml） and induced apoptosis of SO cells. Swelled mitochondria and dilated endoplasmic reticulum as well as disjoined and diminished

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