Monitoring lamivudine therapy in HBV-infected patients by the quantity and structures of circulating viral nucleic acids

张伟; Hans Jrg Hacker; Maria Mildenberger; Claus H.Schrder; 苏勤

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Monitoring lamivudine therapy in HBV-infected patients by the quantity and structures of circulating viral nucleic acids

Updated：2026-03-12

- Monitoring lamivudine therapy in HBV-infected patients by the quantity and structures of circulating viral nucleic acids
- Military Medical Research Issue 3, Pages: 2-174(2003)
- Affiliations：
  
  1. Department of Pathology
  2. Tangdu Hospital
  3. Fourth Military Medical University
  4. ,Germany
  5. Department of Virus-Host Interactions
  6. Deutsches Krebsforschungszentrum Heidelberg
- Author bio：
- Funds：
- DOI：
  CLC： R512.6
- Published：2003
- Accepted：
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[1]张伟,Hans Jrg Hacker,Maria Mildenberger,Claus H.Schrder,苏勤.Monitoring lamivudine therapy in HBV-infected patients by the quantity and structures of circulating viral nucleic acids[J].Journal of Medical Colleges of PLA,2003(03):2-174.
DOI：

[1]张伟,Hans Jrg Hacker,Maria Mildenberger,Claus H.Schrder,苏勤.Monitoring lamivudine therapy in HBV-infected patients by the quantity and structures of circulating viral nucleic acids[J].Journal of Medical Colleges of PLA,2003(03):2-174. DOI：

摘要

Abstract

<正> To monitor the progression of lamivudine therapy by demonstrating HBV DNAs and RNAs in the serum of achronically infected patient. Viral nucleic acids were exracted from serum samples taken during a 14-week treatmentperiod and analyzed via competitive PCR and RT/PCR. The dynamic changes in the amount as well as in the structurescan monitor therapy process very well. Our study indicated the level of polyadenylated viral RNA can be a marker forexpression in general

and the appearance of replicative intermediates as a mirror of the mode of action of an antiviraldrug.

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