<正> Objective: To investigate the relationship between estrogen receptor （ER） gene and the clinical indexes associated with coronary heart disease （ CHD）. Methods: By means of polymerase chain reaction-restriction fragment length polymorphism （PCR-RFLP）

we analyzed ER gene polymorphism in 84 CHD patients and 61 healthy subjects and non-CHD inpatients. The clinical indexes associated with CHD were analyzed in relation to the three ER genotypes. Results: There were significant differences in the incidence of hypertension （58.62% ）

fibrinogen （Fib） concentration （3. 5±0. 8 g/L）

body mass index （BMI

25. 1±3. 2）

HDL-C concentration （1.0±0. 2 mmol/L） between PP genotype group and other genotype groups （P <0. 05）. Conclusion: ER gene polymorphism may affect ER-mediated cardiovascular protective effect by modulating the expression of ER.