<正> Objective: To study the effects of quercetin on hepatocyte stimulating factor production from mouse perito-neal macrophages. Methods: Hepatocyte stimulating factor was evaluated by the amount of fibrinogen synthesized inHep3B cells. Interleukin-6 activity was measured by B9 cell proliferation methyl thiazolyl tetrazolium colorimetric meth-od. Hep3B cell supernatant fibrinogen was quantitated with ELISA. Results: LPS induced the synthesis of hepatocytestimulating factor in mouse peritoneal macrophages

and hepatocyte stimulating factor promotes the synthesis of fibrino-gen from Hep3B cells. Quercetin（5 to 40 μmol/L） inhibited the synthesis of hepatocyte stimulating factor stimulated