<正>Objective:To explore the protective effect of remifentanil on mitochondria in rat hepatocytes subjected to ischemia-reperfusion injury and their possible mechanism. Methods:The model of rat hepatic ischemia-reperfusion injury was used and the effect of remifentanil on the ultrastructure of mitochondria

calcium homeostasis

MDA level in mitochondria were observed. Results: In contrast with the control group

mitochondrial matrix calcium concentration

calcium concentration after calcium uptake

and the quantity of calcium uptake in low and high remifentanil concentration groups and 5-HD group are lower （P<0. 01）

and there is no difference in RHD （5-HD+remifentanil） group. The difference in MDA level between groups is insignificant. Conclusion:Remifentanil at clinical concentrations exerts a protective effect on mitochondria in rat hepatocytes subjected to ischemia-reperfusion injury

in which activating the KATP channel may be involved.