<正>Objective: To investigate the role of peroxisome proliferator-activated receptors δ （PPARδ） in inflammatory reaction and its possible mechanism in adipocyte. Methods :Lentivirus-mediated RNA interference （RNAi） was used to block the expression of PPARS in 3T3-L1 cells. In order to induce inflammation in 3T3-L1

cells were stimulated with tumor necrosis factor-α（TNFα

20 ng/ml） for 4 h. The expression of PPAR8

nuclear factor κB （NFκB） and C reactive protein （CRP） were determined by Western blot analysis. Results:The expression of PPARδ was reduced by 80% after RNAi. Blockage of PPARδ promoted the expression of CRP and NFκB in cells stimulated with TNFα

but had no effect on normal cells. Conclusion: PPARδ is involved in inflammatory reaction in adipocyte. Blockage of PPARδ can promote the inflammation mediated by inflammatory factors and increase the expression of NFκB and CRP in 3T3-L1 cells stimulated with TNFα.