Current hypotheses of pathogenesis of neuronal degeneration in Alzheimer’s disease （AD） have been proposed

including formation of free radicals

oxidative stress

mitochondrial dysfunction

inflammatory processes

genetic factors

environmental impact factors

apoptosis

and so on. Especially

oxidative stress plays an essential role in AD pathogenesis by the function of linking agent. Oxidative stress in AD mainly includes lipid peroxidation

protein oxidation and DNA oxidation. Lipid peroxidation plays a key role in the development and progression of AD. Protein oxidation is an important mechanism in AD. Oxidative damage to DNA may plays an important role in aging and AD.