Effects of Res on proliferation and apoptosis of human cervical carcinoma cell lines C33A,SiHa and HeLa

Shen Xin1; Lv Shulan2; Zhang Jing2; Li Shengnan2; Gao Jiyong2; Pan Cheng’en3 1Department of Anesthesia; First Affiliated Hospital; Medical College; Xi’an Jiaotong University; Xi’an 710061; China 2Department of Obstetrics and Gynecology; China 3Department of Hepatobiliary Surgery; China

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Effects of Res on proliferation and apoptosis of human cervical carcinoma cell lines C33A,SiHa and HeLa

Updated：2026-03-12

- Effects of Res on proliferation and apoptosis of human cervical carcinoma cell lines C33A,SiHa and HeLa
- Military Medical Research Vol. 24, Issue 3, Pages: 148-154(2009)
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  CLC： R737.33
- Published：2009
- Accepted：
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[1].Effects of Res on proliferation and apoptosis of human cervical carcinoma cell lines C33A,SiHa and HeLa[J].Journal of Medical Colleges of PLA,2009,24(03):148-154.
DOI：

[1].Effects of Res on proliferation and apoptosis of human cervical carcinoma cell lines C33A,SiHa and HeLa[J].Journal of Medical Colleges of PLA,2009,24(03):148-154. DOI：

摘要

Abstract

Objective:To explore the effects of Res on the proliferation and apoptosis of human cervical cancer cell lines C33A

SiHa and HeLa.Methods:Inhibition rates by different concentrations of Res were calculated using MTT method.Apoptosis rates and cell cycles were measured and examined by flow cytometry（FCM）.Morphological configuration of apoptotic cells were observed under the fluorescence microscope.Results:The growth of cancer cells was inhibited by Res of varied concentrations in a time-and dose-dependent manner（P<0.01）.The cells showed characteristic apoptosis morphologic changes under fluorescence microscope.Res exerted no effects on cell cycles.Conclusion:Res inhibits the growth of cervical cell lines C33A

SiHa and HeLa by inducing cell apoptosis in a time-and dose-dependent manner.

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