Bone remodeling is performed under the joint action of osteoblasts and osteoclasts. Since the effect of osteoclasts has been gradually recognized on bone and joint diseases

targeted researches toward osteoclasts have become a hot research field. This article reviews the relevant medical literature concerning the possible effects of the fluid shear stress （FSS） on the osteoclastogenesis chiefly from the aspects of RANKL-RANK-OPG system

the macrophage colony-stimulating factor （M-CSF）

and calcitonin receptor （CTR）. On the basis of the changes of the expression of osteoclastic activities

it is suggested that FSS is a potent

important regulator of bone metabolism.