Adenoviral-mediated localized CTLA-4Ig gene expression induces long-term allograft pancreas survival and donor-specific immune tolerance in rats

John Huang

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Adenoviral-mediated localized CTLA-4Ig gene expression induces long-term allograft pancreas survival and donor-specific immune tolerance in rats

Updated：2026-03-12

- Adenoviral-mediated localized CTLA-4Ig gene expression induces long-term allograft pancreas survival and donor-specific immune tolerance in rats
- Military Medical Research Vol. 23, Issue 6, Pages: 313-323(2008)
- Affiliations：
  
  Department of Medicine,University of California
- Author bio：
- Funds：
- DOI：
  CLC： R657.5
- Published：2008
- Accepted：
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[1]John Huang.Adenoviral-mediated localized CTLA-4Ig gene expression induces long-term allograft pancreas survival and donor-specific immune tolerance in rats[J].Journal of Medical Colleges of PLA,2008,23(06):313-323.
DOI：

[1]John Huang.Adenoviral-mediated localized CTLA-4Ig gene expression induces long-term allograft pancreas survival and donor-specific immune tolerance in rats[J].Journal of Medical Colleges of PLA,2008,23(06):313-323. DOI：

摘要

Abstract

T cell activation following alloantigen recognition plays a critical role in the development of the rejection in all solid organ

tissue and cell transplantation. A recombinant molecule

cytotoxic T lymphocyte antigen 4 antibody （CTLA-4Ig）

is known to induce to T-cell into "anergy" by blocking the costimulatory B7-CD28 interaction. Either systemic or localized administration of CTLA-Ig has been shown to prolong allograft survival and induce donor-specific tolerance in some transplant models. In this study

we characterized the expression and immunosuppressive effectiveness of adenoviral-mediated CTLA-4Ig gene transfer. We demonstrated transduction of the allografts with AdCTLA-4Ig resulted in localized expression

permanent graft survival and stable donor-specific tolerance. In addition

by performing simultaneous dual-organ transplantation

we targeted on immunosuppression through a local expression of CTLA-4Ig via adenoviral-mediated gene transfer into pancreatic allografts.

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