Objective:To investigate the association of XRCC4 polymorphic variants at G-1394T（rs6869366） with colorectal cancer susceptibility.Methods:In this hospital-based case-control study

the association of XRCC4 polymorphism with colorectal cancer risk in Chinese population was investigated.In total

171 patients with colorectal cancer and 171 healthy individuals matched for age and gender were selected.The genomic DNAs of the patients and controls were extracted from peripheral blood and the 300 bp target DNA was amplified with Polymerase Chain Reaction.The products were then digested with restriction endonuclease HincII

followed by agarose electrophoresis to identify the genotype.Results:We found a significant difference in the frequency of the XRCC4 G-1394T genotype between the colorectal cancer and control groups in female（1/127 vs 8/122

P<0.05）.Those with G/T at XRCC4 G-1394T showed a decreased risk of colorectal cancer susceptibility compared with those with T/T（OR 0.113

95%CI 0.014-0.932）.However

in overall population or in male

there was no significant difference of the distribution between the colorectal cancer and control groups.Conclusion:Our findings suggested that the G allele of XRCC4 G-1394T were associated with decreased risk of colorectal cancer susceptibility in female.