Gradient decrease in telomerase and its RNA in progressive passage of human endometrial stromal stem cells

Yang Xinyuan1; Wang Wei2; Wang Yueling1; Chen Wei3; Li Xu1 1Department of Gynaecology and Obstetrics; First Affiliated Hospital; School of Medicine; Xi’an Jiaotong University; Xi’an 710061; China 2Department of Anesthesiology; First Affiliated Hospital; School of Medicine; Xi’an Jiaotong University; Xi’an 710061; China 3Department of Clinical Laboratory; First Affiliated Hospital; School of Medicine; Xi’an Jiaotong University; Xi’an 710061; China

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Gradient decrease in telomerase and its RNA in progressive passage of human endometrial stromal stem cells

Updated：2026-03-12

- Gradient decrease in telomerase and its RNA in progressive passage of human endometrial stromal stem cells
- Military Medical Research Vol. 26, Issue 5, Pages: 254-263(2011)
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  CLC： R711.74
- Published：2011
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[1].Gradient decrease in telomerase and its RNA in progressive passage of human endometrial stromal stem cells[J].Journal of Medical Colleges of PLA,2011,26(05):254-263.
DOI：

[1].Gradient decrease in telomerase and its RNA in progressive passage of human endometrial stromal stem cells[J].Journal of Medical Colleges of PLA,2011,26(05):254-263. DOI：

摘要

Abstract

The purpose of this study was to explore the change of telomerase in passage from human endometrial stromal stem cells isolated from human endometrium.Telomerase activity of cultured endometrial stromal cells was assessed at mRNA and protein levels using RT-PCR and immunohistochemistry technique.Telomerase mRNA and protein levels were higher at early passages

and then had a gradually decreased trend of immunoreactive intensity and gradually weakened positive cells with progressive passage in endometrial stromal stem cells.These results suggest that telomerase is contributed to the insenecence of endometrial stem cell.

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