Role of cyclooxygenase-2 in lipid metabolism in hepatic stellate cells

JING Xinyan; YANG Xuefeng; OU Yangyan; QING Kai

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Role of cyclooxygenase-2 in lipid metabolism in hepatic stellate cells

Updated：2026-03-12

- Role of cyclooxygenase-2 in lipid metabolism in hepatic stellate cells
- Military Medical Research Vol. 28, Issue 6, Pages: 373-383(2013)
- Affiliations：
  
  1. Department of Gastroenterology, the Affiliated Nanhua Hospital of the University of South China
  2. Department of Nephrology, Ruijin Hospital, the Shanghai Jiaotong University
  3. Department of Hematology, Ruijin Hospital, the Shanghai Jiaotong University
- Author bio：
- Funds：
- DOI：
  CLC： R329
- Published：2013
- Accepted：
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[1]JING Xinyan,YANG Xuefeng,OU Yangyan,QING Kai.Role of cyclooxygenase-2 in lipid metabolism in hepatic stellate cells[J].Journal of Medical Colleges of PLA,2013,28(06):373-383.
DOI：

[1]JING Xinyan,YANG Xuefeng,OU Yangyan,QING Kai.Role of cyclooxygenase-2 in lipid metabolism in hepatic stellate cells[J].Journal of Medical Colleges of PLA,2013,28(06):373-383. DOI：

摘要

Abstract

Hepatic stellate cells（HSCs） are a kind of adipocytes. In HSCs lipids mainly exist in the form of lipid droplets. They are abundantly found in the cytoplasm and their main constituents are triglycerides. Lipid metabolism in HSCs is closely related to its biological activity

however the mechanism of lipid droplets disappearance after HSC activation is not clearly established yet. Recent research shows that

cyclooxygenase-2 plays an important regulatory role in the lipid metabolism of HSCs. This paper seeks to review the subject based on studies that have been conducted so far to understand the role of cyclooxygenase-2 in the metabolism of lipids in HSCs.

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