An ongoing search for potential targets and therapies for lethal sepsis

Guo-Qiang Bao; Li He; David Lee; John D’Angelo; Hai-Chao Wang

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An ongoing search for potential targets and therapies for lethal sepsis

REVIEW | Updated：2022-12-27

- An ongoing search for potential targets and therapies for lethal sepsis
- Military Medical Research Vol. 2, Issue 3, Pages: 145-155(2015)
- Affiliations：
  
  1.Department of Emergency Medicine, North Shore University Hospital, Manhasset, NY 11030, USA
  2.The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY 11030, USA
  3.Department of General Surgery, Tangdu Hospital, The 4th Military Medical University, Xi’an, Shaanxi 710032, China
  4.Department of Ophthalmology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
- Author bio：
  
  *: hwang@nshs.edu
- Funds：
- DOI：
  CLC：
- Published：2015-09
- Accepted：
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Guo-Qiang Bao, Li He, David Lee, et al. An ongoing search for potential targets and therapies for lethal sepsis[J]. Military Medical Research, 2015, 2(3): 145-155.
DOI：

Guo-Qiang Bao, Li He, David Lee, et al. An ongoing search for potential targets and therapies for lethal sepsis[J]. Military Medical Research, 2015, 2(3): 145-155. DOI：

摘要

Abstract

Sepsis

which refers to a systemic inflammatory response syndrome resulting from a microbial infection

represents the leading cause of death in intensive care units. The pathogenesis of sepsis remains poorly understood although it is attributable to dysregulated immune responses orchestrated by innate immune cells that sequentially release early (e.g.

tumor necrosis factor(TNF)

interleukin-1(IL-1)

and interferon-γ(IFN-γ) and late (e.g.

high mobility group box 1(HMGB1)) pro-inflammatory mediators. As a ubiquitous nuclear protein

HMGB1 can be passively released from pathologically damaged cells

thereby converging infection and injury on commonly dysregulated inflammatory responses. We review evidence that supports extracellular HMGB1 as a late mediator of inflammatory diseases and discuss the potential of several Chinese herbal components as HMGB1-targeting therapies. We propose that it is important to develop strategies for specifically attenuating injury-elicited inflammatory responses without compromising the infection-mediated innate immunity for the clinical management of sepsis and other inflammatory diseases.

关键词

Keywords

references

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