Basic roles of key molecules connected with NMDAR signaling pathway on regulating learning and memory and synaptic plasticity
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Basic roles of key molecules connected with NMDAR signaling pathway on regulating learning and memory and synaptic plasticity
Military Medical ResearchVol. 3, Issue 4, Pages: 212-218(2016)
Affiliations:
Department of Experimental Pathology,Beijing Institute of Radiation Medicine
Author bio:
Funds:
DOI:
CLC:R338
Published:2016
Accepted:
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[1]Hui Wang,Rui-Yun Peng.Basic roles of key molecules connected with NMDAR signaling pathway on regulating learning and memory and synaptic plasticity[J].Military Medical Research,2016,3(04):212-218.
DOI:
[1]Hui Wang,Rui-Yun Peng.Basic roles of key molecules connected with NMDAR signaling pathway on regulating learning and memory and synaptic plasticity[J].Military Medical Research,2016,3(04):212-218.DOI:
Basic roles of key molecules connected with NMDAR signaling pathway on regulating learning and memory and synaptic plasticity
摘要
Abstract
With key roles in essential brain functions ranging from the long-term potentiation(LTP) to synaptic plasticity
the N-methyl-D-aspartic acid receptor(NMDAR) can be considered as one of the fundamental glutamate receptors in the central nervous system.The role of NMDA R was first identified in synaptic plasticity and has been extensively studied.Some molecules
such as Ca
2+
postsynaptic density 95(PSD-95)
calcium/calmodulin-dependent protein kinase II(Ca MK II)
protein kinase A(PKA)
mitogen-activated protein kinase(MAPK) and cyclic adenosine monophosphate(c AMP) responsive element binding protein(CREB)
are of special importance in learning and memory.This review mainly focused on the new research of key molecules connected with learning and memory
which played important roles in the NMDAR signaling pathway.
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