Mesenchymal stem cell therapy for acute radiation syndrome

Risaku Fukumoto

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Mesenchymal stem cell therapy for acute radiation syndrome

EDITORIAL | Updated：2026-03-12

- Mesenchymal stem cell therapy for acute radiation syndrome
- Military Medical Research Vol. 3, Issue 3, Pages: 117-120(2016)
- Affiliations：
  
  Educational-Scientific Center, Faculty of Health Sciences, Medical University of Białystok, ul. Szpitalna 37, 15-295 Białystok, Poland
- Author bio：
  
  risaku_fukumoto@hotmail.com
- Funds：
- DOI：
  CLC：
- Published：2016-09
- Accepted：
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Risaku Fukumoto. Mesenchymal stem cell therapy for acute radiation syndrome[J]. Military Medical Research, 2016, 3(3): 117-120.
DOI：

Risaku Fukumoto. Mesenchymal stem cell therapy for acute radiation syndrome[J]. Military Medical Research, 2016, 3(3): 117-120. DOI：

摘要

Abstract

Acute radiation syndrome affects military personnel and civilians following the uncontrolled dispersal of radiation

such as that caused by detonation of nuclear devices and inappropriate medical treatments. Therefore

there is a growing need for medical interventions that facilitate the improved recovery of victims and patients. One promising approach may be cell therapy

which

when appropriately implemented

may facilitate recovery from whole body injuries. This editorial highlights the current knowledge regarding the use of mesenchymal stem cells for the treatment of acute radiation syndrome

the benefits and limitations of which are under investigation. Establishing successful therapies for acute radiation syndrome may require using such a therapeutic approach in addition to conventional approaches.

关键词

Keywords

references

Bushberg JT . Radiation Exposure and Contamination . http://www.merckmanuals.com/professional/injuries_poisoning/radiation_exposure_and_contamination/radiation_exposure_and_contamination.html http://www.merckmanuals.com/professional/injuries_poisoning/radiation_exposure_and_contamination/radiation_exposure_and_contamination.html .

Acute radiation syndrome . http://en.wikipedia.org/wiki/Acute_radiation_syndrome#cite_note-8 http://en.wikipedia.org/wiki/Acute_radiation_syndrome#cite_note-8 .

Donnelly EH , Nemhauser JB , Smith JM , Kazzi ZN , Farfan EB , Chang AS , et al . Acute radiation syndrome: assessment and management . South Med J . 2010 ; 103 : 541 - 6 .

Waselenko JK , MacVittie TJ , Blakely WF , Pesik N , Wiley AL , Dickerson WE , et al . Medical management of the acute radiation syndrome: recommendations of the Strategic National Stockpile Radiation Working Group . Ann Intern Med . 2004 ; 140 : 1037 - 51 .

Services USDoHH . Regenerative Medicine . http://stemcells.nih.gov/info/scireport/pages/2006report.aspx http://stemcells.nih.gov/info/scireport/pages/2006report.aspx .

Calkoen FG , Brinkman DM , Vervat C , van Ostaijen-Ten Dam MM , Ten Cate R , van Tol MJ , et al . Mesenchymal stromal cells isolated from children with systemic juvenile idiopathic arthritis suppress innate and adaptive immune responses . Cytotherapy . 2013 ; 15 : 280 - 1 .

Askari AT , Unzek S , Popovic ZB , Goldman CK , Forudi F , Kiedrowski M , et al . Effect of stromal-cell-derived factor 1 on stem-cell homing and tissue regeneration in ischaemic cardiomyopathy . Lancet . 2003 ; 362 : 697 - 703 .

Pittenger MF , Mackay AM , Beck SC , Jaiswal RK , Douglas R , Mosca JD , et al . Multilineage potential of adult human mesenchymal stem cells . Science . 1999 ; 284 : 143 - 7 .

Martino G , Pluchino S . The therapeutic potential of neural stem cells . Nat Rev Neurosci . 2006 ; 7 : 395 - 406 .

Seita J , Weissman IL . Hematopoietic stem cell: self-renewal versus differentiation . Wiley Interdiscip Rev Syst Biol Med . 2010 ; 2 : 640 - 53 .

Sokolov M , Neumann R . Lessons learned about human stem cell responses to ionizing radiation exposures: a long road still ahead of us . Int J Molecul Sci . 2013 ; 14 : 15695 - 723 .

Services USDoHH . Hematopoietic Stem Cell Transplant . http://www.remm.nlm.gov/stemcelltransplant.htm http://www.remm.nlm.gov/stemcelltransplant.htm .

Hu KX , Sun QY , Guo M , Ai HS . The radiation protection and therapy effects of mesenchymal stem cells in mice with acute radiation injury . Br J Radiol . 2010 ; 83 : 52 - 8 .

ClinicalTrials.gov . https://clinicaltrials.gov https://clinicaltrials.gov .

Wang L , Li Y , Chen X , Chen J , Gautam SC , Xu Y , et al . MCP-1, MIP-1, IL-8 and ischemic cerebral tissue enhance human bone marrow stromal cell migration in interface culture . Hematology . 2002 ; 7 : 113 - 7 .

Meirelles Lda S , Fontes AM , Covas DT , Caplan AI . Mechanisms involved in the therapeutic properties of mesenchymal stem cells . Cytokine Growth Factor Rev . 2009 ; 20 : 419 - 27 .

Tolar J , Le Blanc K , Keating A , Blazar BR . Concise review: hitting the right spot with mesenchymal stromal cells . Stem Cells . 2010 ; 28 : 1446 - 55 .

Lange C , Brunswig-Spickenheier B , Cappallo-Obermann H , Eggert K , Gehling UM , Rudolph C , et al . Radiation rescue: mesenchymal stromal cells protect from lethal irradiation . PLoS One . 2011 ; 6 : e14486 .

Eaton Jr EB , Varney TR . Mesenchymal stem cell therapy for acute radiation syndrome: innovative medical approaches in military medicine . Mil Med Res . 2015 ; 2 : 2 .

Majumdar MK , Thiede MA , Mosca JD , Moorman M , Gerson SL . Phenotypic and functional comparison of cultures of marrow-derived mesenchymal stem cells (MSCs) and stromal cells . J Cell Physiol . 1998 ; 176 : 57 - 66 .

Mourcin F , Grenier N , Mayol JF , Lataillade JJ , Sotto JJ , Herodin F , et al . Mesenchymal stem cells support expansion of in vitro irradiated CD34(+) cells in the presence of SCF, FLT3 ligand, TPO and IL3: potential application to autologous cell therapy in accidentally irradiated victims . Rad Res . 2005 ; 164 : 1 - 9 .

Wang JF , Wu YF , Harrintong J , McNiece IK . Ex vivo expansions and transplantations of mouse bone marrow-derived hematopoietic stem/progenitor cells . J Zhejiang Univ (Sci) . 2004 ; 5 : 157 - 63 .

Angelopoulou M , Novelli E , Grove JE , Rinder HM , Civin C , Cheng L , et al . Cotransplantation of human mesenchymal stem cells enhances human myelopoiesis and megakaryocytopoiesis in NOD/SCID mice . Exp Hematol . 2003 ; 31 : 413 - 20 .

Fouillard L , Bensidhoum M , Bories D , Bonte H , Lopez M , Moseley AM , et al . Engraftment of allogeneic mesenchymal stem cells in the bone marrow of a patient with severe idiopathic aplastic anemia improves stroma . Leukemia . 2003 ; 17 : 474 - 6 .

Fouillard L , Chapel A , Bories D , Bouchet S , Costa JM , Rouard H , et al . Infusion of allogeneic-related HLA mismatched mesenchymal stem cells for the treatment of incomplete engraftment following autologous haematopoietic stem cell transplantation . Leukemia . 2007 ; 21 : 568 - 70 .

Meuleman N , Tondreau T , Ahmad I , Kwan J , Crokaert F , Delforge A , et al . Infusion of mesenchymal stromal cells can aid hematopoietic recovery following allogeneic hematopoietic stem cell myeloablative transplant: a pilot study . Stem Cells Dev . 2009 ; 18 : 1247 - 52 .

Ball LM , Bernardo ME , Roelofs H , Lankester A , Cometa A , Egeler RM , et al . Cotransplantation of ex vivo expanded mesenchymal stem cells accelerates lymphocyte recovery and may reduce the risk of graft failure in haploidentical hematopoietic stem-cell transplantation . Blood . 2007 ; 110 : 2764 - 7 .

Maitra B , Szekely E , Gjini K , Laughlin MJ , Dennis J , Haynesworth SE , et al . Human mesenchymal stem cells support unrelated donor hematopoietic stem cells and suppress T-cell activation . Bone Marrow Transpl . 2004 ; 33 : 597 - 604 .

Kim DW , Chung YJ , Kim TG , Kim YL , Oh IH . Cotransplantation of third-party mesenchymal stromal cells can alleviate single-donor predominance and increase engraftment from double cord transplantation . Blood . 2004 ; 103 : 1941 - 8 .

Ringden O , Uzunel M , Rasmusson I , Remberger M , Sundberg B , Lonnies H , et al . Mesenchymal stem cells for treatment of therapy-resistant graftversus-host disease . Transplantation . 2006 ; 81 : 1390 - 7 .

Duijvestein M , Vos AC , Roelofs H , Wildenberg ME , Wendrich BB , Verspaget HW , et al . Autologous bone marrow-derived mesenchymal stromal cell treatment for refractory luminal Crohn’s disease: results of a phase I study . Gut . 2010 ; 59 : 1662 - 9 .

Voswinkel J , Francois S , Simon JM , Benderitter M , Gorin NC , Mohty M , et al . Use of mesenchymal stem cells (MSC) in chronic inflammatory fistulizing and fibrotic diseases: a comprehensive review . Clin Rev Allergy Immunol . 2013 ; 45 : 180 - 92 .

Saha S , Bhanja P , Kabarriti R , Liu L , Alfieri AA , Guha C . Bone marrow stromal cell transplantation mitigates radiation-induced gastrointestinal syndrome in mice . PLoS One . 2011 ; 6 : e24072 .

Kim JW , Lee JH , Lyoo YS , Jung DI , Park HM . The effects of topical mesenchymal stem cell transplantation in canine experimental cutaneous wounds . Vet Dermatol . 2013 ; 24 : e242 - 53 .

Hao L , Wang J , Zou Z , Yan G , Dong S , Deng J , et al . Transplantation of BMSCs expressing hPDGF-A/hBD2 promotes wound healing in rats with combined radiation-wound injury . Gene Ther . 2009 ; 16 : 34 - 42 .

Mansilla E , Marin GH , Drago H , Sturla F , Salas E , Gardiner C , et al . Bloodstream cells phenotypically identical to human mesenchymal bone marrow stem cells circulate in large amounts under the influence of acute large skin damage: new evidence for their use in regenerative medicine . Transplant Proc . 2006 ; 38 : 967 - 9 .

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