A specific objective supplemental factor in evaluating acute mountain sickness: ΔHR in combination with SaO<sub>2</sub>

Ming Li; Ji-Hang Zhang; Guo-Xi Zhao; Shi-Zhu Bian; Xu-Bin Gao; Xi Liu; Jie Yu; Jun-Qing Dong; Guo-Zhu Chen; Hong Wang; Lan Huang

Your Location：

Home >

Browse articles >

A specific objective supplemental factor in evaluating acute mountain sickness: ΔHR in combination with SaO₂

RESEARCH | Updated：2022-12-27

- A specific objective supplemental factor in evaluating acute mountain sickness: ΔHR in combination with SaO₂
- Military Medical Research Vol. 2, Issue 3, Pages: 139-144(2015)
- Affiliations：
  
  1.Institute of Cardiovascular Diseases of PLA, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China
  2.Department of Cardiology, 533 Hospital of PLA, Kunming 650000, China
  3.Department of Cadre Wards, Kunming General Hospital of Chengdu Command, Kunming 650032, China
- Author bio：
  
  Hong Wang, Email: Wanghong43@126.com
  *: Lan Huang, Email: huanglan260@126.com;
- Funds：
- DOI：
  CLC：
- Published：2015-09
- Accepted：
Scan QR Code
Ming Li, Ji-Hang Zhang, Guo-Xi Zhao, et al. A specific objective supplemental factor in evaluating acute mountain sickness: ΔHR in combination with SaO₂[J]. Military Medical Research, 2015, 2(3): 139-144.
DOI：

Ming Li, Ji-Hang Zhang, Guo-Xi Zhao, et al. A specific objective supplemental factor in evaluating acute mountain sickness: ΔHR in combination with SaO₂[J]. Military Medical Research, 2015, 2(3): 139-144. DOI：

摘要

Abstract

Background:

So far

there have been no measurements confirmed useful in diagnosing acute mountain sickness (AMS). The aim of this study was to determine the role of heart rate (HR) difference (ΔHR) and oxygen saturation (SaO

) as objective risk factors in aiding the diagnosis of AMS.

Methods:

A total of 1

019 participants were assigned to either the acute exposure group (AEG): from 500m to 3

700m by flight within 2.5 hours (

=752); or the pre-acclimatization group (PAG): ascended to 4

400m from 3

650m within three hours by car after adapting 33 days at 3

650m (

=267). The questionnaires or measurements of resting SaO

and HR were completed between 18 and 24 hours before departure and after arrival.

Results:

Incidence of AMS was 61.3% (461) in AEG

with 46.1% (347) mild cases and 15.2% (114) severe cases. In PAG

the incidence was 38.9% (104)

with 30.7% (82) mild cases and 8.2% (22) severe cases. The AMS subjects showed a significant increase in HR and a decrease in SaO

levels compared with the non-AMS subjects in both groups. ΔHR and post-exposure SaO

were significantly correlated with the Lake Louise Score (LLS) in both groups. Stepwise logistic regression analysis revealed the ΔHR

25 and SaO

88% in AEG as well as ΔHR

15 and SaO

86% in PAG to be independent risk factors of AMS. Combining these two measurements could specifically indicate participants with AMS

which showed a positive predictive value of 89% and specificity of 97% in AEG as well as 85% and 98% in PAG.

Conclusion:

ΔHR or SaO

as objective measurements

correlate with AMS. Combination of these two measurements may be useful as an additional specific and objective factor to further confirm the diagnosis of AMS.

关键词

Keywords

references

Basnyat B , Murdoch DR . High-altitude illness . Lancet . 2003 ; 361 : 1967 - 74 .

Hackett PH , Roach RC . High-altitude illness . N Engl J Med . 2001 ; 345 : 107 - 14 .

Imray CW , A. Subudhi , A.R Roach , . Acute mountain sickness: pathophysiology, prevention, and treatment . Prog Cardiovasc Dis . 2010 ; 52 : 467 - 84 .

Huang L . High altitude medicine in China in the 21st century: opportunities and challenges . Mil Med Res . 2014 ; 1 : 17 .

Karinen HM , Peltonen JE , Kahonen M , Tikkanen HO . Prediction of acute mountain sickness by monitoring arterial oxygen saturation during ascent . High Alt Med Biol . 2010 ; 11 : 325 - 32 .

Roach RC , Bärtsch P , Hackett PH , Oelz O : The Lake Louise acute mountain sickness scoring system . In: Sutton JR , Houston CS , Coates G , eds . Hypoxia and Molecular Medicine . Queen City Printers , Burlington, VT : 1993 . 272 - 4 .

Koehle MS , Guenette JA , Warburton DE . Oximetry, heart rate variability, and the diagnosis of mild-to-moderate acute mountain sickness . Eur J Emerg Med . 2010 ; 17 : 119 - 22 .

O’Connor T , Dubowitz G , Bickler PE . Pulse oximetry in the diagnosis of acute mountain sickness . High Alt Med Biol . 2004 ; 5 : 341 - 8 .

Wu TY , Ding SQ , Zhang SL , Duan JQ , Li BY , Zhan ZY , et al : Altitude illness in Qinghai-Tibet railroad passengers . High Alt Med Biol . 2010 , 11 : 189 - 98 .

Li M , Zhang JH , Bian SZ , Zheng SJ , Gao XB , Yu J , et al : Relationship between oxygen delivery and its compensatory factors and acute mountain sickness . Med J Chin PLA . 2013 ; 38 : 245 - 8 .

Modesti PA , Rapi S , Paniccia R , Bilo G , Revera M , Agostoni P , et al : Index measured at an intermediate altitude to predict impending acute mountain sickness . Med Sci Sports Exerc . 2011 ; 43 : 1811 - 8 .

Riepl RL , Fischer R , Hautmann H , Hartmann G , Muller TD , Tschöp M , et al : Influence of acute exposure to high altitude on Basal and postprandial plasma levels of gastroenteropancreatic peptides . PLoS One . 2012 ; 7 : e44445 .

Burtscher M , Mairer K , Wille M , Broessner G . Risk factors for high-altitude headache in mountaineers . Cephalalgia . 2011 ; 31 : 706 - 11 .

Naeije R . Physiological adaptation of the cardiovascular system to high altitude . Prog Cardiovasc Dis . 2010 ; 52 : 456 - 66 .

Hooper T , Mellor A . Cardiovascular physiology at high altitude . J R Army Med Corps . 2011 ; 157 : 23 - 8 .

Purkayastha SS , Ray US , Arora BS , Chhabra PC , Thakur L , Bandopadhyay P , et al : Acclimatization at high altitude in gradual and acute induction . J Appl Physiol (1985) . 1995 ; 79 : 487 - 92 .

Loeppky JA , Icenogle MV , Maes D , Riboni K , Scotto P , Roach RC . Body temperature, autonomic responses, and acute mountain sickness . High Alt Med Biol . 2003 ; 4 : 367 - 73 .

Burtscher M , Flatz M , Faulhaber M . Prediction of susceptibility to acute mountain sickness by SaO 2 values during short-term exposure to hypoxia . High Alt Med Biol . 2004 ; 5 : 335 - 40 .

Views

Downloads

CSCD

Alert me when the article has been cited

Submit

Tools

Publicity Resources

Association between physiological responses after exercise at low altitude and acute mountain sickness upon ascent is sex-dependent

EPAS1 and VEGFA gene variants are related to the symptoms of acute mountain sickness in Chinese Han population: a cross-sectional study

Sex-based differences in the prevalence of acute mountain sickness: a meta-analysis

Numerical Simulation of 3D Air-Charging Model of the Heavy Haul Train Air Brake Pipes System

Simulation Analysis of Girder Transport Process on the Box Girder of Hangzhou Bay Bridge

Related Author

Lan Huang

Jie Yu

Chen Zhang

Lai-Ping Zhang

Chun-Yan He

Jing-Bin Ke

Fang-Zheng-Yuan Yuan

Hu Tan

Related Institution

Institute of Cardiovascular Diseases of PLA, the Second Affiliated Hospital, Army Medical University

Department of Cardiology, the Second Affiliated Hospital, Army Medical University

Institute of Cardiovascular Diseases, Department of Cardiology, Xinqiao Hospital, Army Medical University

Department of Military Medical Geography, Army Medical Service Training Base, Army Medical University

Department of Military Medical Geography, Third Military Medical University

⁰

A specific objective supplemental factor in evaluating acute mountain sickness: ΔHR in combination with SaO2

DOI：

摘要

Abstract

关键词

Keywords

references

A specific objective supplemental factor in evaluating acute mountain sickness: ΔHR in combination with SaO₂