Effects of omeprazole or pantoprazole on platelet function in non-ST-segment elevation acute coronary syndrome patients receiving clopidogrel

Ruo-Xi Gu; Xiao-Zeng Wang; Jing Li; Jie Deng; Xing-Xing Li; Jiao Wang

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Effects of omeprazole or pantoprazole on platelet function in non-ST-segment elevation acute coronary syndrome patients receiving clopidogrel

RESEARCH | Updated：2022-12-27

- Effects of omeprazole or pantoprazole on platelet function in non-ST-segment elevation acute coronary syndrome patients receiving clopidogrel
- Military Medical Research Vol. 4, Issue 2, Pages: 70-79(2017)
- Affiliations：
  
  Department of Cardiology, General Hospital of Shenyang Military Region, Shenyang 110840, China
- Author bio：
  
  *: wxiaozeng@163.com
- Funds：
- DOI：
  CLC：
- Published：2017-06
- Accepted：
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Ruo-Xi Gu, Xiao-Zeng Wang, Jing Li, et al. Effects of omeprazole or pantoprazole on platelet function in non-ST-segment elevation acute coronary syndrome patients receiving clopidogrel[J]. Military Medical Research, 2017, 4(2): 70-79.
DOI：

Ruo-Xi Gu, Xiao-Zeng Wang, Jing Li, et al. Effects of omeprazole or pantoprazole on platelet function in non-ST-segment elevation acute coronary syndrome patients receiving clopidogrel[J]. Military Medical Research, 2017, 4(2): 70-79. DOI：

摘要

Abstract

Background:

This study evaluated the effect of omeprazole or pantoprazole on platelet reactivity in non-STsegment elevation acute coronary syndrome (NSTE-ACS) patients receiving clopidogrel.

Methods:

Consecutive patients with NSTE-ACS (

=620) from general hospital of Shenyang Military Command were randomized to the omeprazole or pantoprazole (20mg/d) group (1:1)

and received routine dual antiplatelet treatment. Patients’ reversion rate of adenosine diphosphate-induced platelet aggregation (ADP-PA) was assessed at baseline

12 to 24h after administration of medication

and after 72h of percutaneous coronary intervention (PCI). The primary endpoint of the study was platelet reactivity assessed with ADP-PA at 30 days after PCI. Adverse events (AEs) were recorded for 30-day and 180-day follow-up periods.

Results:

There were no significant differences between both the groups in platelet response to clopidogrel at 12–24h after drug administration (54.09%±18.90%

. 51.62%±19.85%

=0.12)

72h after PCI (52.15%±19.45%

. 49.66%±20.05%

=0.18)

and 30 days after PCI (50.44%±14.54%

. 48.52%±15.08%

=0.17). The rate of AEs did not differ significantly between groups during the 30-day (15.2%

. 14.8%

=0.91) and 180-day (16.5%

. 14.5%

=0.50) follow-up periods after PCI.

Conclusion:

The addition of omeprazole or pantoprazole to clopidogrel did not restrict the effect of platelet aggregation by reducing the conversion of clopidogrel. Compared with clopidogrel alone

pantoprazole-clopidogrel and omeprazole-clopidogrel combinations did not increase the incidence of adverse clinical events during 30-day and 180-day follow-up periods after PCI.

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references

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