Improvements in SOD mimic AEOL-10150, a potent broad-spectrum antioxidant

Xiao-rui Zhang; Wen-xia Zhou; Yong-xiang Zhang

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Improvements in SOD mimic AEOL-10150, a potent broad-spectrum antioxidant

Updated：2022-12-27

- Improvements in SOD mimic AEOL-10150, a potent broad-spectrum antioxidant
- Military Medical Research Vol. 6, Issue 1, Pages: 78-88(2019)
- Affiliations：
  
  State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology
- Author bio：
- Funds：
- DOI：
  CLC： R82
- Published：2019
- Accepted：
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[1]Xiao-rui Zhang,Wen-xia Zhou,Yong-xiang Zhang.Improvements in SOD mimic AEOL-10150, a potent broad-spectrum antioxidant[J].Military Medical Research,2019,6(01):78-88.
DOI：

[1]Xiao-rui Zhang,Wen-xia Zhou,Yong-xiang Zhang.Improvements in SOD mimic AEOL-10150, a potent broad-spectrum antioxidant[J].Military Medical Research,2019,6(01):78-88. DOI：

摘要

Abstract

AEOL-10150 is a broad-spectrum metalloporphyrin superoxidase dismutase（SOD） mimic specifically designed to neutralize reactive oxygen and nitrogen species. Research has shown that AEOL-10150 is a potent medical countermeasure against national security threats including sulfur mustard（SM）

nerve agent exposure and radiation pneumonitis following a radiological/nuclear incident sufficient to cause acute radiation syndrome（ARS）. AEOL-10150 performed well in animal safety studies

and two completed phase 1 safety studies in patients demonstrated that the drug was safe and well tolerated

indicating that AEOL-10150 has potential as a new catalytic antioxidant drug. In this article

we review improvements in AEOL-10150 in preclinical pharmacodynamic studies

especially regarding anti-SM

chlorine gas and radiation exposure studies.

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